Our Team

Dr. William Foulkes, MBBS,Ph.D, FRCPC

         Principal Investigator

 

Dr. William Foulkes is a James McGill Professor in the Departments of Medicine, Oncology and Human Genetics at McGill University. He is a researcher-clinician who has practiced clinical cancer genetics at McGill-affiliated hospitals since 1996 and who heads cancer genetics research laboratories at two McGill-affiliated, hospital-based research institutes, the Lady Davis Institute for Medical Research of the Jewish General Hospital and the Research Institute of the McGill University Health Centre. He is a Fellow of the Canadian Academy of Health Sciences, a Fellow of the Royal College of Physicians (London) and in 2016 was elected a Fellow of the Royal Society of Canada. He served as a Komen Scholar between 2010 and 2018.

He is best known for his work on the clinico-pathological features of hereditary breast cancer and for his discovery and characterization of cancer predisposing founder mutations in Montreal populations, including a germline pathogenic missense variant in MSH2 in the Ashkenazim and disease-causing variants in PALB2 and RAD51D in French Canadians. In collaboration with Jacek Majewski, he identified biallelic variants in SMARCA4 as the sole cause of small cell carcinoma of the ovary, hypercalcemic type. He collaborates extensively with medical professionals and researchers around the world to better understand the genetics of various cancers. For the past 10 years, with nearly fifty publications his team extensively defined the phenotypes linked to the DICER1 pleiotropic tumor predisposition syndrome and is now exploring the functional impact of inherited mutations in DICER1. Another recent research focus involves genome-wide characterization of patients with multiples primary tumors to identify the genetic predisposing factors at work in these individuals.

 


Staff

Nancy Hamel
Lab Manager
A McGill graduate in molecular genetics, Nancy joined the lab as a research technician based at the RIMUHC in 1997. Now a research associate, she manages projects at both research sites, assists with grant applications and handles lab finances. She is also responsible for day-to-day management and technical support of fellows and students at the RIMUHC site.
Razia Chanda
Research Coordinator
Razia was the clinical administrative assistant for the Medical Genetics Group at the JGH for over 10 years before joining the lab in 2016 as the research coordinator.
foulkeslab.oncology@mcgill.ca
Nelly Sabbaghian
Research Technician
Nelly has been a research technician with the lab since 2009. She has a wide range of skills in molecular biology and tissue culture techniques. She is based at the LDI site and provides day-to-day management and technical support for fellows and students at that site.
Zoulikha Rezoug
Genetic Counselor, Clinical Research Coordinator

Zoulikha is a former Quality Control auditor who joined the group in 2017. She manages projects on diagnosis of breast cancer with liquid biopsy, prostate cancer in carriers of BRCA1/2 mutations and on the creation of a cancer predisposition genetics biobank. She currently coordinates an important pilot study to offer systematic genetic screening to all women diagnosed with invasive breast cancer at our hospitals.

Javad Nadaf, PhD.
Bio-Computer Scientist
Javad's research has focused on the bioinformatics and statistical analyses of disease-related (Epi)genomic data. He is interested in discovering cancer-predisposing germline variations and deciphering the interplay between the genome, epigenome and transcriptome in formation and progression of cancer. His current projects have mainly focused on deciphering the role of mutations in miRNA processing genes in cancer development.
Maria Apellaniz, PhD.
Postdoctoral Fellow
Maria joined the team in January 2017 after obtaining her PhD in Molecular Biomedicine at the CNIO (Spain). Her research is focused on identifying new cancer susceptibility genes with a particular interest in rare non-epithelial ovarian tumors.
Dominique Geoffrion, B.Sc.
MD-PhD Candidate

Dominique joined the lab as a MSc student in September 2017 after graduating from a Biomedical Sciences Honours degree at University of Montreal. She transferred to the MD-PhD program at McGill in September 2018 and will rejoin our lab to complete her PhD in January 2020.

Supriya Behl, B.Sc.
MSC Candidate
Supriya has been in our lab since the fall of 2017 as a masters student. She is working on identifying rare genetic variants in the French Canadian founder population that predispose women to breast cancer.
HyeRim Han
Research Assistant

HyeRim joined the lab as a research assistant in the Summer of 2017. Her research focuses on cancer susceptibility and signalling pathways in lowgrade brain tumors such as DNETs. She works primarily in collaboration with Dr. Barbara Rivera, former postdoc in our lab.

Anne-Laure Chong
MSC Candidate

Anne-Laure first joined our team as an undergraduate student while completing her BSc at McGill. She completed a research course with our lab and also worked as a summer student. She is now performing functional studies on DICER1 mutations as part of her graduate thesis.

Photo Gallery

 Former lab members

Leanne de Kock, PhD Graduate (2013-2018)

Now a Postdoctoral Fellow at Harry Perkins Institute of Medical Research, University of Western Australia, Perth, Australia

Mona Wu, PhD Graduate (2013-2018)

Cameron Levins, MSc Graduate (2016-2018)

Now a medical student at McGill University, Montreal.

Barbara Rivera, Postdoctoral Fellow (2013-2018)

Now an Assistant Professor at McGill University, Montreal, Canada

Ester Castellsagué, Postdoctoral Fellow (2012-2016)

Now a Medical Writer for CDM Barcelona, Barcelona, Spain

Talia Boshari, Research Coordinator (2014-2016)

Now a Public Health Policy Officer at Southwark Council, London, UK

Leora Witkowski, PhD Graduate (2011-2016)

Now a Postdoctoral Fellow with Dr. Heidi Rehm, Harvard University, Boston, US

Catherine Goudie, Genetics Resident (2015-2016)

Now a Clinician in the Hematology Pediatric dept at MUHC and a Junior Scientist at the RIMUHC, Canada.

Jian Carrot-Zhang PhD Graduate (2010-2016)

Now a Postdoctoral Fellow at the Broad Institute, Boston, US

Ismael Bah, Genetics Resident (2015-2016)

Now a Hematopathology Fellow at MD Anderson Cancer Center

Heidi Rothenmund, Research Genetic Counselor (2011-2015)

Now working for the Health Sciences Centre, Winnipeg, Canada

Andrew Shuen, Genetics Resident (2009-2014)

Now a Medical Geneticist at the London Health Sciences Centre, London, Canada

Nassim Taherian, Research Genetic Counselor (2009-2014)

Now an Oncology Regional Medical Specialist at Myriad Genetics in San Francisco, US

Evan Weber, Research Assistant (2013-2014)

Now working as a Genetic Counselor at the MUHC in Montreal, Canada

Rachel Silva-Smith, Research Assistant (2012-2013)

Now working as a Genetic Counselor at U Miami, US

Luca Cavallone, Research Associate (2011-2013)

Now a Research Associate at McGill University, Montreal, Canada

Sabrina Notte, Administrative Assistant (2005-2013)

Now at home with her two children.

Archana Srivastava, Research Technician (2008-2013)

Now in the Department of Pathology at the LDI in Montreal, Canada

Lili Li, PhD Graduate (2007-2013)

Now a Postdoctoral Fellow at Houston Methodist Research Institute, Weil Cornell Medicine, Houston, US

Amin Bahubeshi, MSc Graduate (2009-2011)

Now a medical student at U of T, Toronto, Canada

François Plourde, Research Genetic Counselor (2009-2011)

Now working as a Genetic Counselor at Dalhousie University in Halifax, Canada

Virginia Manning, Administrative Assistant (2009-2011)

Now a Senior Medical Editor with Roche Pharmaceuticals in London, UK

Emilie Lalonde, MSc Graduate (2009-2011)

Now a Clinical Molecular Genetics Fellow with Dr. Arupa Ganguly, UPenn, US

Deidra Osher, Research Assistant (2008-2011)

Now studying medicine at McGill University, Montreal, Canada

Thomas Rio Frio, Postdoctoral Fellow (2008-2010)

Now a Molecular Genetics Laboratory Manager at Genoma, Switzerland

Martin Couillard, Postdoctoral Fellow (2008-2010)

Now an Advisor in Research and Knowledge transfer at HEC Montreal, Canada

David Novak, MSc Graduate (2007-2009)

Now Managing Director, Equity Research Analyst at Raymond James, Toronto, Canada

Ahmet Yilmaz, Postdoctoral Fellow (2006-2008)

Now in the Pathology Department at Ohio State University, US

Tayma Khalil, MSc Graduate (2005-2007)

Now Senior Director, Strategy, Expedia Group, Geneva

Ioli Makriyianni, MSc Graduate (2003-2005)

Now Senior Associate, Optimus Management Consultants, Toronto